About Endoglin
Endoglin (ENG) is a protein
from Homo sapiens identified by UniProt accession
P17813, 658 residues long.
MolForge cross-references it against 0 known binders and
682 disease associations.
Target properties
| Protein name | Endoglin |
|---|
| UniProt accession | P17813 |
|---|
| Gene | ENG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 658 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (682)
Diseases linked to this target (Open Targets).
- telangiectasia, hereditary hemorrhagic, type 1 · score 0.85
- hereditary hemorrhagic telangiectasia · score 0.80
- vascular disease · score 0.60
- arteriovenous hemangioma/malformation · score 0.59
- congenital anomaly of the great arteries · score 0.57
- Abnormality of the cardiovascular system · score 0.56
- Abnormality of the vasculature · score 0.55
- congenital anomaly of cardiovascular system · score 0.55
- heritable pulmonary arterial hypertension · score 0.47
- pulmonary hypertension, primary, 1 · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17813-F1 | alphafold | PREDICTED | 80.05 | — |
Amino-acid sequence (658 residues)
MDRGTLPLAV ALLLASCSLS PTSLAETVHC DLQPVGPERG EVTYTTSQVS KGCVAQAPNA ILEVHVLFLE FPTGPSQLEL TLQASKQNGT WPREVLLVLS VNSSVFLHLQ ALGIPLHLAY NSSLVTFQEP PGVNTTELPS FPKTQILEWA AERGPITSAA ELNDPQSILL RLGQAQGSLS FCMLEASQDM GRTLEWRPRT PALVRGCHLE GVAGHKEAHI LRVLPGHSAG PRTVTVKVEL SCAPGDLDAV LILQGPPYVS WLIDANHNMQ IWTTGEYSFK IFPEKNIRGF KLPDTPQGLL GEARMLNASI VASFVELPLA SIVSLHASSC GGRLQTSPAP IQTTPPKDTC SPELLMSLIQ TKCADDAMTL VLKKELVAHL KCTITGLTFW DPSCEAEDRG DKFVLRSAYS SCGMQVSASM ISNEAVVNIL SSSSPQRKKV HCLNMDSLSF QLGLYLSPHF LQASNTIEPG QQSFVQVRVS PSVSEFLLQL DSCHLDLGPE GGTVELIQGR AAKGNCVSLL SPSPEGDPRF SFLLHFYTVP IPKTGTLSCT VALRPKTGSQ DQEVHRTVFM RLNIISPDLS GCTSKGLVLP AVLGITFGAF LIGALLTAAL WYIYSHTRSP SKREPVVAVA APASSESSST NHSIGSTQST PCSTSSMA
Explore Endoglin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets