About Probable ATP-dependent RNA helicase DDX5
Probable ATP-dependent RNA helicase DDX5 (DDX5) is a protein
from Homo sapiens identified by UniProt accession
P17844, 614 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX5 |
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| UniProt accession | P17844 |
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| Gene | DDX5 |
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| Organism | Homo sapiens |
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| Length | 614 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (217)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- colon adenocarcinoma · score 0.37
- severe acute respiratory syndrome · score 0.37
- colorectal adenocarcinoma · score 0.37
- hemangioblastoma · score 0.37
- skin squamous cell carcinoma · score 0.37
- gliomatosis cerebri · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- chronic lymphocytic leukemia · score 0.32
- hepatocellular carcinoma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17844-F1 | alphafold | PREDICTED | 76.08 | — |
Amino-acid sequence (614 residues)
MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA APMIGYPMPT GYSQ
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