About X-box-binding protein 1
X-box-binding protein 1 (XBP1) is a protein
from Homo sapiens identified by UniProt accession
P17861, 261 residues long.
MolForge cross-references it against 0 known binders and
309 disease associations.
Target properties
| Protein name | X-box-binding protein 1 |
|---|
| UniProt accession | P17861 |
|---|
| Gene | XBP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (309)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- hemoglobin measurement · score 0.35
- hematocrit · score 0.24
- mean corpuscular hemoglobin · score 0.23
- pancreatic carcinoma · score 0.23
- alkaline phosphatase measurement · score 0.23
- hair shape measurement · score 0.22
- heel bone mineral density · score 0.22
- sex hormone-binding globulin measurement · score 0.22
- mean arterial pressure · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17861-F1 | alphafold | PREDICTED | 68.29 | — |
Amino-acid sequence (261 residues)
MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG RHQPSWKPLM N
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