About Ganglioside GM2 activator
Ganglioside GM2 activator (GM2A) is a protein
from Homo sapiens identified by UniProt accession
P17900, 193 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Ganglioside GM2 activator |
|---|
| UniProt accession | P17900 |
|---|
| Gene | GM2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (118)
Diseases linked to this target (Open Targets).
- GM2-gangliosidosis, AB variant · score 0.81
- Tay-Sachs disease AB variant · score 0.78
- neurodegenerative disease · score 0.55
- lysosomal storage disease · score 0.50
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- Tay-Sachs disease · score 0.45
- Seizure · score 0.37
- FEV/FVC ratio · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17900-F1 | alphafold | PREDICTED | 88.96 | — |
Amino-acid sequence (193 residues)
MQSLMQAPLL IALGLLLAAP AQAHLKKPSQ LSSFSWDNCD EGKDPAVIRS LTLEPDPIIV PGNVTLSVMG STSVPLSSPL KVDLVLEKEV AGLWIKIPCT DYIGSCTFEH FCDVLDMLIP TGEPCPEPLR TYGLPCHCPF KEGTYSLPKS EFVVPDLELP SWLTTGNYRI ESVLSSSGKR LGCIKIAASL KGI
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