About Galectin-3
Galectin-3 (LGALS3) is a protein
from Homo sapiens identified by UniProt accession
P17931, 250 residues long.
MolForge cross-references it against 0 known binders and
1,426 disease associations.
Target properties
| Protein name | Galectin-3 |
|---|
| UniProt accession | P17931 |
|---|
| Gene | LGALS3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 250 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1426)
Diseases linked to this target (Open Targets).
- galectin-3 measurement · score 0.42
- blood protein measurement · score 0.38
- mean platelet volume · score 0.35
- protein measurement · score 0.27
- Red cell distribution width · score 0.25
- reticulocyte count · score 0.23
- leukocyte count · score 0.19
- Immature Reticulocyte Fraction Measurement · score 0.19
- eosinophil count · score 0.18
- erythrocyte count · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17931-F1 | alphafold | PREDICTED | 73.83 | — |
Amino-acid sequence (250 residues)
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI
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