26S proteasome regulatory subunit 6A (PSMC3)

About 26S proteasome regulatory subunit 6A

26S proteasome regulatory subunit 6A (PSMC3) is a protein from Homo sapiens identified by UniProt accession P17980, 439 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 6A
UniProt accession	P17980
Gene	PSMC3
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

Neurodevelopmental disorder · score 0.54
neurodegenerative disease · score 0.52
HIV infection · score 0.46
Microcephaly · score 0.39
scoliosis · score 0.37
Acetabular dysplasia · score 0.37
Global developmental delay · score 0.34
developmental dysplasia of the hip · score 0.34
Microretrognathia · score 0.34
Cerebellar vermis hypoplasia · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17980-F1	alphafold	PREDICTED	80.62	—

Amino-acid sequence (439 residues)

MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS EIKIMKSEVL RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY MEGILEVQAK KKANLQYYA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards