About T-complex protein 1 subunit alpha
T-complex protein 1 subunit alpha (TCP1) is a protein
from Homo sapiens identified by UniProt accession
P17987, 556 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | T-complex protein 1 subunit alpha |
|---|
| UniProt accession | P17987 |
|---|
| Gene | TCP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 556 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- endometrial cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- squamous cell lung carcinoma · score 0.18
- neoplasm · score 0.09
- acute myeloid leukemia · score 0.08
- hepatocellular carcinoma · score 0.07
- cancer · score 0.05
- breast cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17987-F1 | alphafold | PREDICTED | 88.98 | — |
Amino-acid sequence (556 residues)
MEGPLSVFGD RSTGETIRSQ NVMAAASIAN IVKSSLGPVG LDKMLVDDIG DVTITNDGAT ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL LKNADELVKQ KIHPTSVISG YRLACKEAVR YINENLIVNT DELGRDCLIN AAKTSMSSKI IGINGDFFAN MVVDAVLAIK YTDIRGQPRY PVNSVNILKA HGRSQMESML ISGYALNCVV GSQGMPKRIV NAKIACLDFS LQKTKMKLGV QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMCLKYF VEAGAMAVRR VLKRDLKRIA KASGATILST LANLEGEETF EAAMLGQAEE VVQERICDDE LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK RVLESKSVVP GGGAVEAALS IYLENYATSM GSREQLAIAE FARSLLVIPN TLAVNAAQDS TDLVAKLRAF HNEAQVNPER KNLKWIGLDL SNGKPRDNKQ AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD KHGSYEDAVH SGALND
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