About General transcription and DNA repair factor IIH helicase subunit XPD
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a protein
from Homo sapiens identified by UniProt accession
P18074, 760 residues long.
MolForge cross-references it against 0 known binders and
556 disease associations.
Target properties
| Protein name | General transcription and DNA repair factor IIH helicase subunit XPD |
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| UniProt accession | P18074 |
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| Gene | ERCC2 |
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| Organism | Homo sapiens |
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| Length | 760 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (556)
Diseases linked to this target (Open Targets).
- trichothiodystrophy 1, photosensitive · score 0.81
- xeroderma pigmentosum group D · score 0.80
- Xeroderma pigmentosum complementation group D · score 0.80
- cerebrooculofacioskeletal syndrome 2 · score 0.77
- trichothiodystrophy · score 0.66
- xeroderma pigmentosum · score 0.65
- HIV infection · score 0.59
- urinary bladder carcinoma · score 0.59
- urinary bladder cancer · score 0.54
- genetic disorder · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18074-F1 | alphafold | PREDICTED | 87.58 | — |
Amino-acid sequence (760 residues)
MKLNVDGLLV YFPYDYIYPE QFSYMRELKR TLDAKGHGVL EMPSGTGKTV SLLALIMAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LNFYEKQEGE KLPFLGLALS SRKNLCIHPE VTPLRFGKDV DGKCHSLTAS YVRAQYQHDT SLPHCRFYEE FDAHGREVPL PAGIYNLDDL KALGRRQGWC PYFLARYSIL HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID NVCIDSMSVN LTRRTLDRCQ GNLETLQKTV LRIKETDEQR LRDEYRRLVE GLREASAARE TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV QESPPAFLSG LAQRVCIQRK PLRFCAERLR SLLHTLEITD LADFSPLTLL ANFATLVSTY AKGFTIIIEP FDDRTPTIAN PILHFSCMDA SLAIKPVFER FQSVIITSGT LSPLDIYPKI LDFHPVTMAT FTMTLARVCL CPMIIGRGND QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT SYQYMESTVA SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND FLTFDAMRHA AQCVGRAIRG KTDYGLMVFA DKRFARGDKR GKLPRWIQEH LTDANLNLTV DEGVQVAKYF LRQMAQPFHR EDQLGLSLLS LEQLESEETL KRIEQIAQQL
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