Bone morphogenetic protein 7 (BMP7)

About Bone morphogenetic protein 7

Bone morphogenetic protein 7 (BMP7) is a protein from Homo sapiens identified by UniProt accession P18075, 431 residues long. MolForge cross-references it against 0 known binders and 685 disease associations.

Target properties

Protein name	Bone morphogenetic protein 7
UniProt accession	P18075
Gene	BMP7
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (685)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.50
high density lipoprotein cholesterol measurement · score 0.44
corneal topography · score 0.44
apolipoprotein A 1 measurement · score 0.42
nose morphology measurement · score 0.41
synophrys measurement · score 0.33
congenital heart disease · score 0.33
ventricular septal defect 1 · score 0.33
metopic craniosynostosis · score 0.33
triglyceride measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18075-F1	alphafold	PREDICTED	76.18	—

Amino-acid sequence (431 residues)

MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY RNMVVRACGC H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards