About ADP-ribosylation factor 4
ADP-ribosylation factor 4 (ARF4) is a protein
from Homo sapiens identified by UniProt accession
P18085, 180 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | ADP-ribosylation factor 4 |
|---|
| UniProt accession | P18085 |
|---|
| Gene | ARF4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 180 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- blood protein measurement · score 0.21
- hepatocellular carcinoma · score 0.15
- leukocyte count · score 0.15
- brain volume measurement · score 0.12
- body weight · score 0.10
- heel bone mineral density · score 0.09
- Heterotaxia · score 0.04
- glycoprotein storage disease · score 0.04
- idiopathic hypereosinophilic syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18085-F1 | alphafold | PREDICTED | 83.83 | — |
Amino-acid sequence (180 residues)
MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN ICFTVWDVGG QDRIRPLWKH YFQNTQGLIF VVDSNDRERI QEVADELQKM LLVDELRDAV LLLFANKQDL PNAMAISEMT DKLGLQSLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR
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