Early growth response protein 1 (EGR1)

About Early growth response protein 1

Early growth response protein 1 (EGR1) is a protein from Homo sapiens identified by UniProt accession P18146, 543 residues long. MolForge cross-references it against 0 known binders and 777 disease associations.

Target properties

Protein name	Early growth response protein 1
UniProt accession	P18146
Gene	EGR1
Organism	Homo sapiens
Length	543 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (777)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
sex hormone-binding globulin measurement · score 0.32
testosterone measurement · score 0.28
hepatocellular carcinoma · score 0.12
squamous cell carcinoma · score 0.12
neoplasm · score 0.12
pain · score 0.11
infection · score 0.10
infect · score 0.10
breast cancer · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18146-F1	alphafold	PREDICTED	49.64	—

Amino-acid sequence (543 residues)

MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGAPEGSGS NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS SASASQSPPL SCAVPSNDSS PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY PAAKGGFQVP MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS RSDELTRHIR IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI CGRKFARSDE RKRHTKIHLR QKDKKADKSV VASSATSSLS SYPSPVATSY PSPVTTSYPS PATTSYPSPV PTSFSSPGSS TYPSPVHSGF PSPSVATTYS SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI EIC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards