Glutathione peroxidase 2 (GPX2)

About Glutathione peroxidase 2

Glutathione peroxidase 2 (GPX2) is a protein from Homo sapiens identified by UniProt accession P18283, 190 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Glutathione peroxidase 2
UniProt accession	P18283
Gene	GPX2
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
acute myeloid leukemia · score 0.25
breast adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.22
endometrial cancer · score 0.18
cutaneous melanoma · score 0.16
non-small cell lung carcinoma · score 0.11
neoplasm · score 0.11
breast cancer · score 0.08
hepatocellular carcinoma · score 0.08

3D Structure

Predicted structure for P18283 is available from the AlphaFold Protein Structure Database.

Amino-acid sequence (190 residues)

MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards