Lipopolysaccharide-binding protein (LBP)

About Lipopolysaccharide-binding protein

Lipopolysaccharide-binding protein (LBP) is a protein from Homo sapiens identified by UniProt accession P18428, 481 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.

Target properties

Protein name	Lipopolysaccharide-binding protein
UniProt accession	P18428
Gene	LBP
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (298)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.51
glioblastoma multiforme · score 0.23
ovarian cancer · score 0.23
thyroid gland adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.22
endometrial cancer · score 0.21
low grade glioma · score 0.18
cutaneous melanoma · score 0.18
lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18428-F1	alphafold	PREDICTED	90.54	—

Amino-acid sequence (481 residues)

MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFL FLGANVQYMR V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards