Arylamine N-acetyltransferase 1 (NAT1)

About Arylamine N-acetyltransferase 1

Arylamine N-acetyltransferase 1 (NAT1) is a protein from Homo sapiens identified by UniProt accession P18440, 290 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Arylamine N-acetyltransferase 1
UniProt accession	P18440
Gene	NAT1
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

urate measurement · score 0.31
bone density · score 0.31
neurodegenerative disease · score 0.20
breast cancer · score 0.09
neoplasm · score 0.08
glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.07
Isolated anophthalmia - microphthalmia · score 0.06
triple-negative breast cancer · score 0.06
microphthalmia · score 0.06
cancer · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18440-F1	alphafold	PREDICTED	98.19	—

Amino-acid sequence (290 residues)

MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards