About Pituitary adenylate cyclase-activating polypeptide
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) is a protein
from Homo sapiens identified by UniProt accession
P18509, 176 residues long.
MolForge cross-references it against 0 known binders and
473 disease associations.
Target properties
| Protein name | Pituitary adenylate cyclase-activating polypeptide |
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| UniProt accession | P18509 |
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| Gene | ADCYAP1 |
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| Organism | Homo sapiens |
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| Length | 176 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (473)
Diseases linked to this target (Open Targets).
- insulin like growth factor measurement · score 0.29
- IGF-1 measurement · score 0.27
- soluble interleukin-2 receptor subunit alpha measurement · score 0.24
- gestational serum measurement · score 0.24
- fetal genotype effect measurement · score 0.24
- protein measurement · score 0.24
- pancreas volume · score 0.22
- migraine disorder · score 0.11
- post-traumatic stress disorder · score 0.10
- experimental autoimmune encephalomyelitis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18509-F1 | alphafold | PREDICTED | 62.57 | — |
Amino-acid sequence (176 residues)
MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL PDFDGSEPPG AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS AGKHLQSLVA RGVGGSLGGG AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL
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