Interleukin-1 receptor antagonist protein (IL1RN)

About Interleukin-1 receptor antagonist protein

Interleukin-1 receptor antagonist protein (IL1RN) is a protein from Homo sapiens identified by UniProt accession P18510, 177 residues long. MolForge cross-references it against 0 known binders and 589 disease associations.

Target properties

Protein name	Interleukin-1 receptor antagonist protein
UniProt accession	P18510
Gene	IL1RN
Organism	Homo sapiens
Length	177 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (589)

Diseases linked to this target (Open Targets).

sterile multifocal osteomyelitis with periostitis and pustulosis · score 0.77
C-reactive protein measurement · score 0.45
neutrophil count · score 0.42
leukocyte count · score 0.42
Red cell distribution width · score 0.40
mean corpuscular hemoglobin concentration · score 0.40
platelet count · score 0.39
alkaline phosphatase measurement · score 0.38
fibrinogen measurement · score 0.38
diabetic nephropathy · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18510-F1	alphafold	PREDICTED	87.04	—

Amino-acid sequence (177 residues)

MEICRGLRSH LITLLLFLFH SETICRPSGR KSSKMQAFRI WDVNQKTFYL RNNQLVAGYL QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSENRKQD KRFAFIRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDEGVMVTK FYFQEDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards