Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic…

About Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G) is a protein from Homo sapiens identified by UniProt accession P18545, 87 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt accession	P18545
Gene	PDE6G
Organism	Homo sapiens
Length	87 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.72
coronary artery disease · score 0.55
stroke · score 0.55
Hepatitis, Alcoholic · score 0.48
diabetic nephropathy · score 0.47
chronic kidney disease · score 0.47
Myocardial Ischemia · score 0.47
diabetes mellitus · score 0.46
non-alcoholic steatohepatitis · score 0.45
cardiovascular disease · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18545-F1	alphafold	PREDICTED	67.31	—

Amino-acid sequence (87 residues)

MNLEPPKAEF RSATRVAGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G)