Negative elongation factor E (NELFE)

About Negative elongation factor E

Negative elongation factor E (NELFE) is a protein from Homo sapiens identified by UniProt accession P18615, 380 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Negative elongation factor E
UniProt accession	P18615
Gene	NELFE
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
neurodegenerative disease · score 0.38
Iridocyclitis · score 0.34
ankylosing spondylitis · score 0.30
blood protein measurement · score 0.23
breast adenocarcinoma · score 0.23
visual perception measurement · score 0.21
endometrial cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
trichohepatoenteric syndrome · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18615-F1	alphafold	PREDICTED	63.96	—

Amino-acid sequence (380 residues)

MLVIPPGLSE EEEALQKKFN KLKKKKKALL ALKKQSSSST TSQGGVKRSL SEQPVMDTAT ATEQAKQLVK SGAISAIKAE TKNSGFKRSR TLEGKLKDPE KGPVPTFQPF QRSISADDDL QESSRRPQRK SLYESFVSSS DRLRELGPDG EEAEGPGAGD GPPRSFDWGY EERSGAHSSA SPPRSRSRDR SHERNRDRDR DRERDRDRDR DRDRERDRDR DRDRDRDRER DRDRERDRDR DREGPFRRSD SFPERRAPRK GNTLYVYGED MTPTLLRGAF SPFGNIIDLS MDPPRNCAFV TYEKMESADQ AVAELNGTQV ESVQLKVNIA RKQPMLDAAT GKSVWGSLAV QNSPKGCHRD KRTQIVYSDD VYKENLVDGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards