About Lymphocyte activation gene 3 protein
Lymphocyte activation gene 3 protein (LAG3) is a protein
from Homo sapiens identified by UniProt accession
P18627, 525 residues long.
MolForge cross-references it against 0 known binders and
466 disease associations.
Target properties
| Protein name | Lymphocyte activation gene 3 protein |
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| UniProt accession | P18627 |
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| Gene | LAG3 |
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| Organism | Homo sapiens |
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| Length | 525 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (466)
Diseases linked to this target (Open Targets).
- melanoma · score 0.42
- colorectal cancer · score 0.34
- sex hormone-binding globulin measurement · score 0.31
- blood protein measurement · score 0.27
- Hodgkins lymphoma · score 0.27
- colorectal neoplasm · score 0.26
- serum gamma-glutamyl transferase measurement · score 0.25
- neoplasm · score 0.14
- cancer · score 0.13
- non-small cell lung carcinoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18627-F1 | alphafold | PREDICTED | 78.35 | — |
Amino-acid sequence (525 residues)
MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL
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