About Phosphoglycerate mutase 1
Phosphoglycerate mutase 1 (PGAM1) is a protein
from Homo sapiens identified by UniProt accession
P18669, 254 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Phosphoglycerate mutase 1 |
|---|
| UniProt accession | P18669 |
|---|
| Gene | PGAM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.09
- cancer · score 0.09
- breast cancer · score 0.08
- non-small cell lung carcinoma · score 0.08
- oral squamous cell carcinoma · score 0.08
- serum alanine aminotransferase measurement · score 0.05
- serum gamma-glutamyl transferase measurement · score 0.05
- BMI-adjusted waist circumference · score 0.04
- neutrophil count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18669-F1 | alphafold | PREDICTED | 94.35 | — |
Amino-acid sequence (254 residues)
MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG KAKK
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