About Syndecan-1
Syndecan-1 (SDC1) is a protein
from Homo sapiens identified by UniProt accession
P18827, 310 residues long.
MolForge cross-references it against 0 known binders and
814 disease associations.
Target properties
| Protein name | Syndecan-1 |
|---|
| UniProt accession | P18827 |
|---|
| Gene | SDC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 310 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (814)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.56
- total cholesterol measurement · score 0.43
- testosterone measurement · score 0.43
- apolipoprotein A 1 measurement · score 0.41
- sex hormone-binding globulin measurement · score 0.40
- low density lipoprotein cholesterol measurement · score 0.38
- body height · score 0.34
- serum albumin measurement · score 0.34
- triglyceride measurement · score 0.34
- serum urea measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18827-F1 | alphafold | PREDICTED | 55.21 | — |
Amino-acid sequence (310 residues)
MRRAALWLWL CALALSLQPA LPQIVATNLP PEDQDGSGDD SDNFSGSGAG ALQDITLSQQ TPSTWKDTQL LTAIPTSPEP TGLEATAAST STLPAGEGPK EGEAVVLPEV EPGLTAREQE ATPRPRETTQ LPTTHLASTT TATTAQEPAT SHPHRDMQPG HHETSTPAGP SQADLHTPHT EDGGPSATER AAEDGASSQL PAAEGSGEQD FTFETSGENT AVVAVEPDRR NQSPVDQGAT GASQGLLDRK EVLGGVIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ KPTKQEEFYA
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