Cyclic AMP-dependent transcription factor ATF-1 (ATF1)

About Cyclic AMP-dependent transcription factor ATF-1

Cyclic AMP-dependent transcription factor ATF-1 (ATF1) is a protein from Homo sapiens identified by UniProt accession P18846, 271 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Cyclic AMP-dependent transcription factor ATF-1
UniProt accession	P18846
Gene	ATF1
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

melanoma · score 0.37
clear cell sarcoma · score 0.37
cutaneous melanoma · score 0.37
cutaneous fibrous histiocytoma · score 0.37
synovial sarcoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
malignant peripheral nerve sheath tumor · score 0.37
liposarcoma · score 0.37
Ocular Melanoma · score 0.37
undifferentiated pleomorphic sarcoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18846-F1	alphafold	PREDICTED	64.83	—

Amino-acid sequence (271 residues)

MEDSHKSTTS ETAPQPGSAV QGAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKAHGILAR RPSYRKILKD LSSEDTRGRK GDGENSGVSA AVTSMSVPTP IYQTSSGQYI AIAPNGALQL ASPGTDGVQG LQTLTMTNSG STQQGTTILQ YAQTSDGQQI LVPSNQVVVQ TASGDMQTYQ IRTTPSATSL PQTVVMTSPV TLTSQTTKTD DPQLKREIRL MKNREAAREC RRKKKEYVKC LENRVAVLEN QNKTLIEELK TLKDLYSNKS V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards