Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

About Cyclic AMP-dependent transcription factor ATF-3

Cyclic AMP-dependent transcription factor ATF-3 (ATF3) is a protein from Homo sapiens identified by UniProt accession P18847, 181 residues long. MolForge cross-references it against 0 known binders and 511 disease associations.

Target properties

Protein name	Cyclic AMP-dependent transcription factor ATF-3
UniProt accession	P18847
Gene	ATF3
Organism	Homo sapiens
Length	181 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (511)

Diseases linked to this target (Open Targets).

basophil count · score 0.15
eosinophil count · score 0.15
neutrophil count · score 0.15
platelet count · score 0.15
mean platelet volume · score 0.15
erythrocyte count · score 0.15
mean corpuscular volume · score 0.15
mean corpuscular hemoglobin concentration · score 0.15
leukocyte count · score 0.15
monocyte count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18847-F1	alphafold	PREDICTED	75.89	—

Amino-acid sequence (181 residues)

MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards