Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

About Cyclic AMP-dependent transcription factor ATF-4

Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a protein from Homo sapiens identified by UniProt accession P18848, 351 residues long. MolForge cross-references it against 0 known binders and 523 disease associations.

Target properties

Protein name	Cyclic AMP-dependent transcription factor ATF-4
UniProt accession	P18848
Gene	ATF4
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (523)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
lysosomal storage disease · score 0.37
mean corpuscular volume · score 0.32
mean corpuscular hemoglobin concentration · score 0.31
mean corpuscular hemoglobin · score 0.28
Immature Reticulocyte Fraction Measurement · score 0.25
reticulocyte measurement · score 0.22
neurotic disorder · score 0.20
protein measurement · score 0.15
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18848-F1	alphafold	PREDICTED	62.00	—

Amino-acid sequence (351 residues)

MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards