About Cyclic AMP-dependent transcription factor ATF-6 alpha
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) is a protein
from Homo sapiens identified by UniProt accession
P18850, 670 residues long.
MolForge cross-references it against 0 known binders and
394 disease associations.
Target properties
| Protein name | Cyclic AMP-dependent transcription factor ATF-6 alpha |
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| UniProt accession | P18850 |
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| Gene | ATF6 |
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| Organism | Homo sapiens |
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| Length | 670 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (394)
Diseases linked to this target (Open Targets).
- achromatopsia · score 0.71
- Cone rod dystrophy · score 0.38
- total blood protein measurement · score 0.29
- Macular dystrophy · score 0.26
- monocyte count · score 0.26
- serum alanine aminotransferase measurement · score 0.24
- neutrophil count · score 0.23
- leukocyte count · score 0.20
- genetic disorder · score 0.19
- basophil percentage of leukocytes · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18850-F1 | alphafold | PREDICTED | 55.21 | — |
Amino-acid sequence (670 residues)
MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ PKPLLLPAAP KTQTNSSVPA KTIIIQTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV VQLQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG FSAKEAQDTS DGIIQKNSYR YDHSVSNDKA LMVLTEEPLL YIPPPPCQPL INTTESLRLN HELRGWVHRH EVERTKSRRM TNNQQKTRIL QGALEQGSNS QLMAVQYTET TSSISRNSGS ELQVYYASPR SYQDFFEAIR RRGDTFYVVS FRRDHLLLPA TTHNKTTRPK MSIVLPAINI NENVINGQDY EVMMQIDCQV MDTRILHIKS SSVPPYLRDQ QRNQTNTFFG SPPAATEATH VVSTIPESLQ
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