ATP synthase peripheral stalk subunit F6…

About ATP synthase peripheral stalk subunit F6, mitochondrial

ATP synthase peripheral stalk subunit F6, mitochondrial (ATP5PF) is a protein from Homo sapiens identified by UniProt accession P18859, 108 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	ATP synthase peripheral stalk subunit F6, mitochondrial
UniProt accession	P18859
Gene	ATP5PF
Organism	Homo sapiens
Length	108 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

pulmonary arterial hypertension · score 0.08
erythrocyte count · score 0.08
red blood cell density measurement · score 0.08
hemoglobin measurement · score 0.06
rheumatoid arthritis · score 0.03
neoplasm · score 0.03
cardiovascular disease · score 0.03
preeclampsia · score 0.03
gut microbiome measurement · score 0.02
endothelial dysfunction · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18859-F1	alphafold	PREDICTED	83.33	—

Amino-acid sequence (108 residues)

MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

ATP synthase peripheral stalk subunit F6, mitochondrial (ATP5PF)