About DNA repair protein XRCC1
DNA repair protein XRCC1 (XRCC1) is a protein
from Homo sapiens identified by UniProt accession
P18887, 633 residues long.
MolForge cross-references it against 0 known binders and
356 disease associations.
Target properties
| Protein name | DNA repair protein XRCC1 |
|---|
| UniProt accession | P18887 |
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| Gene | XRCC1 |
|---|
| Organism | Homo sapiens |
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| Length | 633 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (356)
Diseases linked to this target (Open Targets).
- Adult-onset autosomal recessive cerebellar ataxia · score 0.66
- laryngeal squamous cell carcinoma · score 0.48
- neurodegenerative disease · score 0.26
- breast adenocarcinoma · score 0.24
- body height · score 0.20
- ovarian cancer · score 0.18
- low density lipoprotein cholesterol measurement · score 0.16
- glioblastoma multiforme · score 0.13
- apolipoprotein B measurement · score 0.12
- appendicular lean mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18887-F1 | alphafold | PREDICTED | 69.42 | — |
Amino-acid sequence (633 residues)
MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA
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