Keratin, type I cytoskeletal 15 (KRT15)

About Keratin, type I cytoskeletal 15

Keratin, type I cytoskeletal 15 (KRT15) is a protein from Homo sapiens identified by UniProt accession P19012, 456 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 15
UniProt accession	P19012
Gene	KRT15
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (191)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.19
prostate adenocarcinoma · score 0.19
clear cell renal carcinoma · score 0.18
glioblastoma multiforme · score 0.18
esophageal cancer · score 0.14
Alzheimer disease · score 0.14
multiple sclerosis · score 0.14
neurodegenerative disease · score 0.14
lysosomal storage disease · score 0.14
Parkinson disease · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19012-F1	alphafold	PREDICTED	74.18	—

Amino-acid sequence (456 residues)

MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards