Keratin, type II cytoskeletal 4 (KRT4)

About Keratin, type II cytoskeletal 4

Keratin, type II cytoskeletal 4 (KRT4) is a protein from Homo sapiens identified by UniProt accession P19013, 520 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.

Target properties

Protein name	Keratin, type II cytoskeletal 4
UniProt accession	P19013
Gene	KRT4
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (176)

Diseases linked to this target (Open Targets).

White sponge nevus · score 0.64
white sponge nevus 1 · score 0.62
head and neck squamous cell carcinoma · score 0.19
genetic disorder · score 0.19
prostate adenocarcinoma · score 0.19
glioblastoma multiforme · score 0.19
clear cell renal carcinoma · score 0.18
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19013-F1	alphafold	PREDICTED	69.13	—

Amino-acid sequence (520 residues)

MIARQQCVRG GPRGFSCGSA IVGGGKRGAF SSVSMSGGAG RCSSGGFGSR SLYNLRGNKS ISMSVAGSRQ GACFGGAGGF GTGGFGGGFG GSFSGKGGPG FPVCPAGGIQ EVTINQSLLT PLHVEIDPEI QKVRTEEREQ IKLLNNKFAS FIDKVQFLEQ QNKVLETKWN LLQQQTTTTS SKNLEPLFET YLSVLRKQLD TLGNDKGRLQ SELKTMQDSV EDFKTKYEEE INKRTAAEND FVVLKKDVDA AYLNKVELEA KVDSLNDEIN FLKVLYDAEL SQMQTHVSDT SVVLSMDNNR NLDLDSIIAE VRAQYEEIAQ RSKAEAEALY QTKVQQLQIS VDQHGDNLKN TKSEIAELNR MIQRLRAEIE NIKKQCQTLQ VSVADAEQRG ENALKDAHSK RVELEAALQQ AKEELARMLR EYQELMSVKL ALDIEIATYR KLLEGEEYRM SGECQSAVSI SVVSGSTSTG GISGGLGSGS GFGLSSGFGS GSGSGFGFGG SVSGSSSSKI ISTTTLNKRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards