About Tetraspanin-8
Tetraspanin-8 (TSPAN8) is a protein
from Homo sapiens identified by UniProt accession
P19075, 237 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Tetraspanin-8 |
|---|
| UniProt accession | P19075 |
|---|
| Gene | TSPAN8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 237 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (185)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.46
- asthma · score 0.33
- diabetes mellitus · score 0.33
- osteoarthritis, spine · score 0.31
- neurofibrillary tangles measurement · score 0.31
- acne · score 0.31
- balding measurement · score 0.30
- Inhalant adrenergic use measurement · score 0.29
- body weight · score 0.23
- complication · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19075-F1 | alphafold | PREDICTED | 87.48 | — |
Amino-acid sequence (237 residues)
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
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