About Guanine nucleotide-binding protein G(t) subunit alpha-2
Guanine nucleotide-binding protein G(t) subunit alpha-2 (GNAT2) is a protein
from Homo sapiens identified by UniProt accession
P19087, 354 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein G(t) subunit alpha-2 |
|---|
| UniProt accession | P19087 |
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| Gene | GNAT2 |
|---|
| Organism | Homo sapiens |
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| Length | 354 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- achromatopsia · score 0.71
- cone dystrophy · score 0.43
- Progressive cone dystrophy · score 0.38
- Retinal dystrophy · score 0.33
- endometrial cancer · score 0.26
- Abnormality of the eye · score 0.26
- body mass index · score 0.25
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.23
- physical activity measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19087-F1 | alphafold | PREDICTED | 93.98 | — |
Amino-acid sequence (354 residues)
MGSGASAEDK ELAKRSKELE KKLQEDADKE AKTVKLLLLG AGESGKSTIV KQMKIIHQDG YSPEECLEFK AIIYGNVLQS ILAIIRAMTT LGIDYAEPSC ADDGRQLNNL ADSIEEGTMP PELVEVIRRL WKDGGVQACF ERAAEYQLND SASYYLNQLE RITDPEYLPS EQDVLRSRVK TTGIIETKFS VKDLNFRMFD VGGQRSERKK WIHCFEGVTC IIFCAALSAY DMVLVEDDEV NRMHESLHLF NSICNHKFFA ATSIVLFLNK KDLFEEKIKK VHLSICFPEY DGNNSYDDAG NYIKSQFLDL NMRKDVKEIY SHMTCATDTQ NVKFVFDAVT DIIIKENLKD CGLF
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