About Cytochrome P450 11B2, mitochondrial
Cytochrome P450 11B2, mitochondrial (CYP11B2) is a protein
from Homo sapiens identified by UniProt accession
P19099, 503 residues long.
MolForge cross-references it against 0 known binders and
324 disease associations.
Target properties
| Protein name | Cytochrome P450 11B2, mitochondrial |
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| UniProt accession | P19099 |
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| Gene | CYP11B2 |
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| Organism | Homo sapiens |
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| Length | 503 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (324)
Diseases linked to this target (Open Targets).
- corticosterone methyloxidase type 2 deficiency · score 0.75
- familial hypoaldosteronism · score 0.55
- steroid inherited metabolic disorder · score 0.50
- Cushing syndrome · score 0.48
- glucocorticoid-remediable aldosteronism · score 0.43
- adrenal gland hyperfunction · score 0.37
- familial hyperreninemic hypoaldosteronism type 2 · score 0.37
- adrenal gland disease · score 0.37
- hypertension · score 0.32
- systolic blood pressure · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19099-F1 | alphafold | PREDICTED | 89.73 | — |
Amino-acid sequence (503 residues)
MALRAKAEVC VAAPWLSLQR ARALGTRAAR APRTVLPFEA MPQHPGNRWL RLLQIWREQG YEHLHLEMHQ TFQELGPIFR YNLGGPRMVC VMLPEDVEKL QQVDSLHPCR MILEPWVAYR QHRGHKCGVF LLNGPEWRFN RLRLNPDVLS PKAVQRFLPM VDAVARDFSQ ALKKKVLQNA RGSLTLDVQP SIFHYTIEAS NLALFGERLG LVGHSPSSAS LNFLHALEVM FKSTVQLMFM PRSLSRWISP KVWKEHFEAW DCIFQYGDNC IQKIYQELAF NRPQHYTGIV AELLLKAELS LEAIKANSME LTAGSVDTTA FPLLMTLFEL ARNPDVQQIL RQESLAAAAS ISEHPQKATT ELPLLRAALK ETLRLYPVGL FLERVVSSDL VLQNYHIPAG TLVQVFLYSL GRNAALFPRP ERYNPQRWLD IRGSGRNFHH VPFGFGMRQC LGRRLAEAEM LLLLHHVLKH FLVETLTQED IKMVYSFILR PGTSPLLTFR AIN
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