About Myosin regulatory light chain 12A
Myosin regulatory light chain 12A (MYL12A) is a protein
from Homo sapiens identified by UniProt accession
P19105, 171 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Myosin regulatory light chain 12A |
|---|
| UniProt accession | P19105 |
|---|
| Gene | MYL12A |
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| Organism | Homo sapiens |
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| Length | 171 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- QRS duration · score 0.20
- breast adenocarcinoma · score 0.18
- dehydrated hereditary stomatocytosis · score 0.05
- Rh deficiency syndrome · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- familial pseudohyperkalemia · score 0.05
- PHF-tau measurement · score 0.05
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19105-F1 | alphafold | PREDICTED | 83.42 | — |
Amino-acid sequence (171 residues)
MSSKRTKTKT KKRPQRATSN VFAMFDQSQI QEFKEAFNMI DQNRDGFIDK EDLHDMLASL GKNPTDEYLD AMMNEAPGPI NFTMFLTMFG EKLNGTDPED VIRNAFACFD EEATGTIQED YLRELLTTMG DRFTDEEVDE LYREAPIDKK GNFNYIEFTR ILKHGAKDKD D
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