About Histidine decarboxylase
Histidine decarboxylase (HDC) is a protein
from Homo sapiens identified by UniProt accession
P19113, 662 residues long.
MolForge cross-references it against 0 known binders and
178 disease associations.
Target properties
| Protein name | Histidine decarboxylase |
|---|
| UniProt accession | P19113 |
|---|
| Gene | HDC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 662 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (178)
Diseases linked to this target (Open Targets).
- Tourette syndrome · score 0.44
- basophil count · score 0.39
- monocyte count · score 0.17
- platelet count · score 0.10
- cutaneous melanoma · score 0.10
- basophil percentage of leukocytes · score 0.08
- neoplasm · score 0.08
- cancer · score 0.08
- Monoamine oxidase A deficiency · score 0.06
- microangiopathy and leukoencephalopathy, pontine, autosomal dominant · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19113-F1 | alphafold | PREDICTED | 80.44 | — |
Amino-acid sequence (662 residues)
MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV SESTLIALLA ARKNKILEMK TSEPDADESC LNARLVAYAS DQAHSSVEKA GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF VCATLGTTGV CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ IPLSRRFRSV KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI PAKRHLGLVV FRLKGPNCLT ENVLKEIAKA GRLFLIPATI QDKLIIRFTV TSQFTTRDDI LRDWNLIRDA ATLILSQHCT SQPSPRVGNL ISQIRGARAW ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL HLETLLDPVD DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG LQLPCCPLQA MV
Explore Histidine decarboxylase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets