About Erythropoietin receptor
Erythropoietin receptor (EPOR) is a protein
from Homo sapiens identified by UniProt accession
P19235, 508 residues long.
MolForge cross-references it against 0 known binders and
546 disease associations.
Target properties
| Protein name | Erythropoietin receptor |
|---|
| UniProt accession | P19235 |
|---|
| Gene | EPOR |
|---|
| Organism | Homo sapiens |
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| Length | 508 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (546)
Diseases linked to this target (Open Targets).
- primary familial polycythemia due to EPO receptor mutation · score 0.63
- chronic kidney disease · score 0.61
- anemia (phenotype) · score 0.60
- myelodysplastic syndrome · score 0.56
- kidney disease · score 0.55
- anemia · score 0.53
- acute graft vs. host disease · score 0.51
- cancer · score 0.50
- chronic renal failure syndrome · score 0.50
- acute myocardial infarction · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19235-F1 | alphafold | PREDICTED | 66.93 | — |
Amino-acid sequence (508 residues)
MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKAA LLAARGPEEL LCFTERLEDL VCFWEEAASA GVGPGNYSFS YQLEDEPWKL CRLHQAPTAR GAVRFWCSLP TADTSSFVPL ELRVTAASGA PRYHRVIHIN EVVLLDAPVG LVARLADESG HVVLRWLPPP ETPMTSHIRY EVDVSAGNGA GSVQRVEILE GRTECVLSNL RGRTRYTFAV RARMAEPSFG GFWSAWSEPV SLLTPSDLDP LILTLSLILV VILVLLTVLA LLSHRRALKQ KIWPGIPSPE SEFEGLFTTH KGNFQLWLYQ NDGCLWWSPC TPFTEDPPAS LEVLSERCWG TMQAVEPGTD DEGPLLEPVG SEHAQDTYLV LDKWLLPRNP PSEDLPGPGG SVDIVAMDEG SEASSCSSAL ASKPSPEGAS AASFEYTILD PSSQLLRPWT LCPELPPTPP HLKYLYLVVS DSGISTDYSS GDSQGAQGGL SDGPYSNPYE NSLIPAAEPL PPSYVACS
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