Lymphocyte function-associated antigen 3 (CD58)

About Lymphocyte function-associated antigen 3

Lymphocyte function-associated antigen 3 (CD58) is a protein from Homo sapiens identified by UniProt accession P19256, 250 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.

Target properties

Protein name	Lymphocyte function-associated antigen 3
UniProt accession	P19256
Gene	CD58
Organism	Homo sapiens
Length	250 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (184)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.46
primary biliary cirrhosis · score 0.41
diffuse large B-cell lymphoma · score 0.38
systemic lupus erythematosus · score 0.35
non-Hodgkins lymphoma · score 0.34
cystatin C measurement · score 0.34
serum urea measurement · score 0.28
creatinine measurement · score 0.28
diastolic blood pressure · score 0.27
neutrophil count · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19256-F1	alphafold	PREDICTED	82.96	—

Amino-acid sequence (250 residues)

MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC DRKPDRTNSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards