DNA-directed RNA polymerase II subunit RPB3 (POLR2C)

About DNA-directed RNA polymerase II subunit RPB3

DNA-directed RNA polymerase II subunit RPB3 (POLR2C) is a protein from Homo sapiens identified by UniProt accession P19387, 275 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase II subunit RPB3
UniProt accession	P19387
Gene	POLR2C
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
influenza · score 0.37
acrocephalosyndactyly · score 0.37
genetic non-acquired premature ovarian failure · score 0.32
breast adenocarcinoma · score 0.28
endometrial cancer · score 0.28
lung adenocarcinoma · score 0.27
neurodegenerative disease · score 0.26
cutaneous melanoma · score 0.24
primary ovarian insufficiency · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19387-F1	alphafold	PREDICTED	92.05	—

Amino-acid sequence (275 residues)

MPYANQPTVR ITELTDENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV QIDANSSVLH DEFIAHRLGL IPLISDDIVD KLQYSRDCTC EEFCPECSVE FTLDVRCNED QTRHVTSRDL ISNSPRVIPV TSRNRDNDPN DYVEQDDILI VKLRKGQELR LRAYAKKGFG KEHAKWNPTA GVAFEYDPDN ALRHTVYPKP EEWPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR PETIVLSALS GLKKKLSDLQ TQLSHEIQSD VLTIN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards