About DNA-directed RNA polymerases I, II, and III subunit RPABC1
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) is a protein
from Homo sapiens identified by UniProt accession
P19388, 210 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
|---|
| UniProt accession | P19388 |
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| Gene | POLR2E |
|---|
| Organism | Homo sapiens |
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| Length | 210 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.60
- neurodegenerative disease · score 0.46
- influenza · score 0.37
- acrocephalosyndactyly · score 0.37
- Short stature · score 0.33
- acute myeloid leukemia · score 0.29
- lung adenocarcinoma · score 0.27
- squamous cell lung carcinoma · score 0.18
- myeloid white cell count · score 0.18
- mean platelet volume · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19388-F1 | alphafold | PREDICTED | 93.08 | — |
Amino-acid sequence (210 residues)
MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE GRPRRTDLTV LVAHNDDPTD QMFVFFPEEP KVGIKTIKVY CQRMQEENIT RALIVVQQGM TPSAKQSLVD MAPKYILEQF LQQELLINIT EHELVPEHVV MTKEEVTELL ARYKLRENQL PRIQAGDPVA RYFGIKRGQV VKIIRPSETA GRYITYRLVQ
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