ETS domain-containing protein Elk-1 (ELK1)

About ETS domain-containing protein Elk-1

ETS domain-containing protein Elk-1 (ELK1) is a protein from Homo sapiens identified by UniProt accession P19419, 428 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	ETS domain-containing protein Elk-1
UniProt accession	P19419
Gene	ELK1
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

infectious disease · score 0.37
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
spermatogenic failure 55 · score 0.07
spermatogenic failure 3 · score 0.07
hyperinsulinism due to INSR deficiency · score 0.07
spermatogenic failure 7 · score 0.07
spermatogenic failure 29 · score 0.06
partial chromosome Y deletion · score 0.06
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19419-F1	alphafold	PREDICTED	58.31	—

Amino-acid sequence (428 residues)

MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTST MPNVAPAAIH AAPGDTVSGK PGTPKGAGMA GPGGLARSSR NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV LPSAAPAGAA APPSGSRSTS PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL GRALPPEVKV EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP ALTPSLLPTH TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS GSAQVHIPSI SVDGLSTPVV LSPGPQKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards