About Glutathione hydrolase 1 proenzyme
Glutathione hydrolase 1 proenzyme (GGT1) is a protein
from Homo sapiens identified by UniProt accession
P19440, 569 residues long.
MolForge cross-references it against 0 known binders and
322 disease associations.
Target properties
| Protein name | Glutathione hydrolase 1 proenzyme |
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| UniProt accession | P19440 |
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| Gene | GGT1 |
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| Organism | Homo sapiens |
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| Length | 569 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (322)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.69
- gamma-glutamyl transpeptidase deficiency · score 0.48
- inborn errors of metabolism · score 0.46
- urinary metabolite measurement · score 0.38
- calcium measurement · score 0.26
- alcoholic liver disease · score 0.25
- serum metabolite measurement · score 0.24
- blood metabolite measurement · score 0.18
- liver fibrosis measurement · score 0.18
- non-alcoholic fatty liver disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19440-F1 | alphafold | PREDICTED | 94.80 | — |
Amino-acid sequence (569 residues)
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF IAVVQAIVRT AGGWAAASDS RKGGEPAGY
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