About General transcription and DNA repair factor IIH helicase/translocase subunit XPB
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (ERCC3) is a protein
from Homo sapiens identified by UniProt accession
P19447, 782 residues long.
MolForge cross-references it against 0 known binders and
226 disease associations.
Target properties
| Protein name | General transcription and DNA repair factor IIH helicase/translocase subunit XPB |
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| UniProt accession | P19447 |
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| Gene | ERCC3 |
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| Organism | Homo sapiens |
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| Length | 782 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (226)
Diseases linked to this target (Open Targets).
- xeroderma pigmentosum group B · score 0.78
- trichothiodystrophy 2, photosensitive · score 0.67
- xeroderma pigmentosum · score 0.66
- Xeroderma pigmentosum complementation group B · score 0.64
- trichothiodystrophy · score 0.60
- HIV infection · score 0.59
- genetic disorder · score 0.47
- colon adenocarcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- cutaneous melanoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19447-F1 | alphafold | PREDICTED | 75.92 | — |
Amino-acid sequence (782 residues)
MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG TKVDEYGAKD YRLQMPLKDD HTSRPLWVAP DGHIFLEAFS PVYKYAQDFL VAIAEPVCRP THVHEYKLTA YSLYAAVSVG LQTSDITEYL RKLSKTGVPD GIMQFIKLCT VSYGKVKLVL KHNRYFVESC HPDVIQHLLQ DPVIRECRLR NSEGEATELI TETFTSKSAI SKTAESSGGP STSRVTDPQG KSDIPMDLFD FYEQMDKDEE EEEETQTVSF EVKQEMIEEL QKRCIHLEYP LLAEYDFRND SVNPDINIDL KPTAVLRPYQ EKSLRKMFGN GRARSGVIVL PCGAGKSLVG VTAACTVRKR CLVLGNSAVS VEQWKAQFKM WSTIDDSQIC RFTSDAKDKP IGCSVAISTY SMLGHTTKRS WEAERVMEWL KTQEWGLMIL DEVHTIPAKM FRRVLTIVQA HCKLGLTATL VREDDKIVDL NFLIGPKLYE ANWMELQNNG YIAKVQCAEV WCPMSPEFYR EYVAIKTKKR ILLYTMNPNK FRACQFLIKF HERRNDKIIV FADNVFALKE YAIRLNKPYI YGPTSQGERM QILQNFKHNP KINTIFISKV GDTSFDLPEA NVLIQISSHG GSRRQEAQRL GRVLRAKKGM VAEEYNAFFY SLVSQDTQEM AYSTKRQRFL VDQGYSFKVI TKLAGMEEED LAFSTKEEQQ QLLQKVLAAT DLDAEEEVVA GEFGSRSSQA SRRFGTMSSM SGADDTVYME YHSSRSKAPS KHVHPLFKRF RK
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