E3 ubiquitin-protein ligase TRIM21 (TRIM21)

About E3 ubiquitin-protein ligase TRIM21

E3 ubiquitin-protein ligase TRIM21 (TRIM21) is a protein from Homo sapiens identified by UniProt accession P19474, 475 residues long. MolForge cross-references it against 0 known binders and 455 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM21
UniProt accession	P19474
Gene	TRIM21
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (455)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.23
ovarian cancer · score 0.21
glioblastoma multiforme · score 0.19
clear cell renal carcinoma · score 0.19
squamous cell lung carcinoma · score 0.14
head and neck squamous cell carcinoma · score 0.14
Systemic lupus erythematosus · score 0.12
systemic scleroderma · score 0.11
neoplasm · score 0.11
interstitial lung disease · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19474-F1	alphafold	PREDICTED	90.66	—

Amino-acid sequence (475 residues)

MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH RDHAMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AIKRADWKKT VETQKSRIHA EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGEKEAKLAQ QSQALQELIS ELDRRCHSSA LELLQEVIIV LERSESWNLK DLDITSPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGKNTAPL TLCPLNIGSQ GSTDY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards