Transcription factor EB (TFEB)

About Transcription factor EB

Transcription factor EB (TFEB) is a protein from Homo sapiens identified by UniProt accession P19484, 476 residues long. MolForge cross-references it against 0 known binders and 462 disease associations.

Target properties

Protein name	Transcription factor EB
UniProt accession	P19484
Gene	TFEB
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (462)

Diseases linked to this target (Open Targets).

gastric carcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
lymphoid neoplasm · score 0.37
breast ductal adenocarcinoma · score 0.37
cutaneous melanoma · score 0.37
Hepatobiliary Neoplasm · score 0.37
glomerular filtration rate · score 0.36
creatinine measurement · score 0.36
serum albumin measurement · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19484-F1	alphafold	PREDICTED	63.18	—

Amino-acid sequence (476 residues)

MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ QQQQLGGPPT PAINTPVHFQ SPPPVPGEVL KVQSYLENPT SYHLQQSQHQ KVREYLSETY GNKFAAHISP AQGSPKPPPA ASPGVRAGHV LSSSAGNSAP NSPMAMLHIG SNPERELDDV IDNIMRLDDV LGYINPEMQM PNTLPLSSSH LNVYSSDPQV TASLVGVTSS SCPADLTQKR ELTDAESRAL AKERQKKDNH NLIERRRRFN INDRIKELGM LIPKANDLDV RWNKGTILKA SVDYIRRMQK DLQKSRELEN HSRRLEMTNK QLWLRIQELE MQARVHGLPT TSPSGMNMAE LAQQVVKQEL PSEEGPGEAL MLGAEVPDPE PLPALPPQAP LPLPTQPPSP FHHLDFSHSL SFGGREDEGP PGYPEPLAPG HGSPFPSLSK KDLDLMLLDD SLLPLASDPL LSTMSPEASK ASSRRSSFSM EEGDVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards