About Interferon-induced, double-stranded RNA-activated protein kinase
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) is a protein
from Homo sapiens identified by UniProt accession
P19525, 551 residues long.
MolForge cross-references it against 0 known binders and
411 disease associations.
Target properties
| Protein name | Interferon-induced, double-stranded RNA-activated protein kinase |
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| UniProt accession | P19525 |
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| Gene | EIF2AK2 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (411)
Diseases linked to this target (Open Targets).
- leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome · score 0.64
- dystonia 33 · score 0.54
- neurodegenerative disease · score 0.53
- HIV infection · score 0.51
- viral disease · score 0.39
- influenza · score 0.37
- early-onset generalized limb-onset dystonia · score 0.37
- adolescent idiopathic scoliosis · score 0.27
- Cognitive impairment · score 0.27
- aspartate aminotransferase measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19525-F1 | alphafold | PREDICTED | 76.32 | — |
Amino-acid sequence (551 residues)
MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR EFPEGEGRSK KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN YIGLINRIAQ KKRLTVNYEQ CASGVHGPEG FHYKCKMGQK EYSIGTGSTK QEAKQLAAKL AYLQILSEET SVKSDYLSSG SFATTCESQS NSLVTSTLAS ESSSEGDFSA DTSEINSNSD SLNSSSLLMN GLRNNQRKAK RSLAPRFDLP DMKETKYTVD KRFGMDFKEI ELIGSGGFGQ VFKAKHRIDG KTYVIKRVKY NNEKAEREVK ALAKLDHVNI VHYNGCWDGF DYDPETSDDS LESSDYDPEN SKNSSRSKTK CLFIQMEFCD KGTLEQWIEK RRGEKLDKVL ALELFEQITK GVDYIHSKKL IHRDLKPSNI FLVDTKQVKI GDFGLVTSLK NDGKRTRSKG TLRYMSPEQI SSQDYGKEVD LYALGLILAE LLHVCDTAFE TSKFFTDLRD GIISDIFDKK EKTLLQKLLS KKPEDRPNTS EILRTLTVWK KSPEKNERHT C
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