Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)

About Galactoside alpha-(1,2)-fucosyltransferase 1

Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) is a protein from Homo sapiens identified by UniProt accession P19526, 365 residues long. MolForge cross-references it against 0 known binders and 537 disease associations.

Target properties

Protein name	Galactoside alpha-(1,2)-fucosyltransferase 1
UniProt accession	P19526
Gene	FUT1
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (537)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.29
urinary albumin to creatinine ratio · score 0.28
albuminuria · score 0.27
bombay phenotype · score 0.24
sodium measurement · score 0.24
low density lipoprotein cholesterol measurement · score 0.23
apolipoprotein B measurement · score 0.22
total cholesterol measurement · score 0.22
serum non-albumin protein measurement · score 0.22
neurodegenerative disease · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19526-F1	alphafold	PREDICTED	87.90	—

Amino-acid sequence (365 residues)

MWLRSHRQLC LAFLLVCVLS VIFFLHIHQD SFPHGLGLSI LCPDRRLVTP PVAIFCLPGT AMGPNASSSC PQHPASLSGT WTVYPNGRFG NQMGQYATLL ALAQLNGRRA FILPAMHAAL APVFRITLPV LAPEVDSRTP WRELQLHDWM SEEYADLRDP FLKLSGFPCS WTFFHHLREQ IRREFTLHDH LREEAQSVLG QLRLGRTGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDSA YLRQAMDWFR ARHEAPVFVV TSNGMEWCKE NIDTSQGDVT FAGDGQEATP WKDFALLTQC NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPLW TLAKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards