About Transcription factor E3
Transcription factor E3 (TFE3) is a protein
from Homo sapiens identified by UniProt accession
P19532, 575 residues long.
MolForge cross-references it against 0 known binders and
283 disease associations.
Target properties
| Protein name | Transcription factor E3 |
|---|
| UniProt accession | P19532 |
|---|
| Gene | TFE3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 575 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (283)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies · score 0.75
- genetic disorder · score 0.41
- renal cell carcinoma · score 0.40
- renal cell carcinoma, Xp11-associated · score 0.40
- Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions · score 0.40
- alveolar soft part sarcoma · score 0.38
- renal carcinoma · score 0.37
- Paraganglioma · score 0.37
- colon adenocarcinoma · score 0.37
- alveolar rhabdomyosarcoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19532-F1 | alphafold | PREDICTED | 58.65 | — |
Amino-acid sequence (575 residues)
MSHAAEPARD GVEASAEGPR AVFVLLEERR PADSAQLLSL NSLLPESGIV ADIELENVLD PDSFYELKSQ PLPLRSSLPI SLQATPATPA TLSASSSAGG SRTPAMSSSS SSRVLLRQQL MRAQAQEQER RERREQAAAA PFPSPAPASP AISVVGVSAG GHTLSRPPPA QVPREVLKVQ THLENPTRYH LQQARRQQVK QYLSTTLGPK LASQALTPPP GPASAQPLPA PEAAHTTGPT GSAPNSPMAL LTIGSSSEKE IDDVIDEIIS LESSYNDEML SYLPGGTTGL QLPSTLPVSG NLLDVYSSQG VATPAITVSN SCPAELPNIK REISETEAKA LLKERQKKDN HNLIERRRRF NINDRIKELG TLIPKSSDPE MRWNKGTILK ASVDYIRKLQ KEQQRSKDLE SRQRSLEQAN RSLQLRIQEL ELQAQIHGLP VPPTPGLLSL ATTSASDSLK PEQLDIEEEG RPGAATFHVG GGPAQNAPHQ QPPAPPSDAL LDLHFPSDHL GDLGDPFHLG LEDILMEEEE GVVGGLSGGA LSPLRAASDP LLSSVSPAVS KASSRRSSFS MEEES
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