Wilms tumor protein (WT1)

About Wilms tumor protein

Wilms tumor protein (WT1) is a protein from Homo sapiens identified by UniProt accession P19544, 449 residues long. MolForge cross-references it against 0 known binders and 984 disease associations.

Target properties

Protein name	Wilms tumor protein
UniProt accession	P19544
Gene	WT1
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (984)

Diseases linked to this target (Open Targets).

Wilms tumor 1 · score 0.80
Denys-Drash syndrome · score 0.80
Frasier syndrome · score 0.77
nephrotic syndrome, type 4 · score 0.74
Meacham syndrome · score 0.73
Malignant Mesothelioma · score 0.66
hereditary Wilms tumor · score 0.62
WAGR syndrome · score 0.57
familial idiopathic steroid-resistant nephrotic syndrome · score 0.56
acute myeloid leukemia · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19544-F1	alphafold	PREDICTED	50.80	—

Amino-acid sequence (449 residues)

MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGV AAGSSSSVKW TEGQSNHSTG YESDNHTTPI LCGAQYRIHT HGVFRGIQDV RRVPGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS EKPFSCRWPS CQKKFARSDE LVRHHNMHQR NMTKLQLAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards