Homeobox protein engrailed-2 (EN2)

About Homeobox protein engrailed-2

Homeobox protein engrailed-2 (EN2) is a protein from Homo sapiens identified by UniProt accession P19622, 333 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	Homeobox protein engrailed-2
UniProt accession	P19622
Gene	EN2
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

Anti-cytomegalovirus IgG measurement · score 0.28
viral load · score 0.24
breast milk measurement · score 0.24
autism · score 0.15
pachyonychia congenita · score 0.08
benign prostatic hyperplasia · score 0.08
Spinocerebellar ataxia type 41 · score 0.08
esophageal squamous cell carcinoma · score 0.07
Joubert syndrome · score 0.07
Autism · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19622-F1	alphafold	PREDICTED	60.17	—

Amino-acid sequence (333 residues)

MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSGP RSRKPKKKNP NKEDKRPRTA FTAEQLQRLK AEFQTNRYLT EQRRQSLAQE LSLNESQIKI WFQNKRAKIK KATGNKNTLA VHLMAQGLYN HSTTAKEGKS DSE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards