Casein kinase II subunit alpha' (CSNK2A2)

About Casein kinase II subunit alpha'

Casein kinase II subunit alpha' (CSNK2A2) is a protein from Homo sapiens identified by UniProt accession P19784, 350 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.

Target properties

Protein name	Casein kinase II subunit alpha'
UniProt accession	P19784
Gene	CSNK2A2
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (15)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (191)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
neuroinflammatory disorder · score 0.32
Parkinson disease · score 0.32
Alzheimer disease · score 0.32
lysosomal storage disease · score 0.32
multiple sclerosis · score 0.32
breast adenocarcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.25
endometrial cancer · score 0.25
telomere length · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19784-F1	alphafold	PREDICTED	94.14	—

Amino-acid sequence (350 residues)

MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards