C-X-C motif chemokine 2 (CXCL2)

About C-X-C motif chemokine 2

C-X-C motif chemokine 2 (CXCL2) is a protein from Homo sapiens identified by UniProt accession P19875, 107 residues long. MolForge cross-references it against 0 known binders and 562 disease associations.

Target properties

Protein name	C-X-C motif chemokine 2
UniProt accession	P19875
Gene	CXCL2
Organism	Homo sapiens
Length	107 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (562)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.65
neutrophil percentage of leukocytes · score 0.49
lymphocyte percentage of leukocytes · score 0.43
leukocyte count · score 0.40
basophil percentage of leukocytes · score 0.35
monocyte percentage of leukocytes · score 0.34
monocyte count · score 0.32
myeloid white cell count · score 0.32
eosinophil percentage of leukocytes · score 0.31
neutrophil-to-lymphocyte ratio · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19875-F1	alphafold	PREDICTED	81.63	—

Amino-acid sequence (107 residues)

MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards